Heterodinuclear Pt(iv)–Ru(ii) anticancer prodrugs to combat both drug resistance and tumor metastasis?
Chemical Communications Pub Date: 2016-08-02 DOI: 10.1039/C6CC04354B
Abstract
A novel approach to design bimetallic anticancer drug candidates with the capability to combat both drug resistance and tumor metastasis is reported. These water-soluble bifunctional Pt(IV)–Ru(II) heterodinuclear complexes with a unique mode of action display up to 2-orders of magnitude enhanced cytotoxicity in cisplatin-resistant cells and significantly impede cancer cell migration.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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