Gold catalysis on immobilized substrates: a heteroannulation approach to the solid-supported synthesis of indoles?

Organic & Biomolecular Chemistry Pub Date: 2012-01-19 DOI: 10.1039/C2OB06881H

Abstract

A gold-catalyzed cyclization of immobilized 2-alkynylanilines was developed as the key step in the synthetic sequence for the preparation of 2-substituted indoles. These results demonstrate the potential of the unexplored combination of gold catalysis and solid-phase organic synthesis.

Graphical abstract: Gold catalysis on immobilized substrates: a heteroannulation approach to the solid-supported synthesis of indoles
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