Gold–carbene assisted formation of tetraarylmethane derivatives: double X–H activation by gold?

Organic & Biomolecular Chemistry Pub Date: 2019-04-18 DOI: 10.1039/C9OB00470J

Abstract

An efficient gold–carbene promoted generation of tetraarylmethane derivatives from enynones and indoles was accomplished by the formation of a new C–O bond and two C–C bonds. It is significant that (2-furyl) gold–carbene assisted addition of two nucleophiles resulted in the formation of tetraarylmethane derivatives with a quaternary centre in moderate to good yields in one pot.

Graphical abstract: Gold–carbene assisted formation of tetraarylmethane derivatives: double X–H activation by gold
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