A new diastereoselective synthesis of a 1β-methylcarbapenem intermediate
Chemical Communications Pub Date: 1900-01-01 DOI: 10.1039/A907922J
Abstract
A 1β-methylcarbapenem key intermediate is synthesized from methyl (R)-3-hydroxybutyrate via the diastereoselective alkylation and regioselective cuprate ring opening of a chiral epoxide which is readily prepared from Sharpless asymmetric epoxidation of the corresponding allylic alcohol.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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