Gas chromatographic determination of volatile anaesthetic agents in blood. Part 2. Clinical studies
ANALYSTANALYST Pub Date: DOI: 10.1039/AN9891401211
Abstract
A method is described for the direct determination of the volatile anaesthetics halothane and isoflurane in blood by gas chromatography with flame-ionisation detection. The method is accurate and precise and allows rapid measurements of blood levels of anaesthetic agents. Headspace concentrations of anaesthetic agents in the concentration range 0–3%V/V are determined with an accuracy of ±0.01%V/V. The relative standard deviation of these results is less than 4.0%. A relatively small volume of blood is required for each determination, a factor of great significance in the treatment of children. The need for separate blood calibration graphs for each patient is discussed, further emphasising the need for a rapid calibration procedure. The results from the clinical application of this method show conclusively its suitability for the management of anaesthetised subjects.
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Journal Name：ANALYSTANALYST
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CAS no.: 89640-58-4
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