Functional bisphosphonate synthesis for the development of new anti-resorption bone drug candidates?
New Journal of Chemistry Pub Date: 2019-07-18 DOI: 10.1039/C9NJ02504A
Abstract
Herein we present the synthesis of β-mono and β-bis-substituted vinylidenebisphosphonate esters bearing a carboxylic ester moiety to be used as building blocks for further functionalizations. Reactions of these new bisphosphonate scaffolds through hydrogenation of the unsaturated C![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
C bond and through metal mediated addition of aryl boronic acids and indoles provide a wide range of new bisphosphonate products as potential leads to contrast osteoporosis.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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