Highly enantioselective Michael addition reactions of 2-substituted benzofuran-3(2H)-ones to nitroolefins?
Organic & Biomolecular Chemistry Pub Date: 2015-09-02 DOI: 10.1039/C5OB01691F
Abstract
A highly enantioselective Michael addition reaction of 2-substituted benzofuran-3(2H)-ones to nitroolefins was promoted by a bifunctional squaramide catalyst. As a result, a number of chiral 2,2′-substituted benzofuran-3-one derivatives, bearing adjacent quaternary–tertiary stereocenters, were efficiently synthesized with excellent enantioselectivities.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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