Highly efficient and general enantioselective synthesis of naturally occurring isoquinoline alkaloids?

Organic Chemistry Frontiers Pub Date: 2014-03-21 DOI: 10.1039/C4QO00058G

Abstract

The highly efficient asymmetric synthesis of (+)-dysoxyline (three steps) and (+)-crispine A (four steps) from readily available different terminal alkynes, benzaldehyde, and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline has been achieved, providing efficient general approaches for achieving libraries of naturally occurring chiral isoquinoline alkaloids.

Graphical abstract: Highly efficient and general enantioselective synthesis of naturally occurring isoquinoline alkaloids
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