Glycoconjugate synthesis using chemoselective ligation?
Organic & Biomolecular Chemistry Pub Date: 2019-02-12 DOI: 10.1039/C9OB00270G
Abstract
Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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