Green organocatalytic α-hydroxylation of ketones?
Organic & Biomolecular Chemistry Pub Date: 2016-02-08 DOI: 10.1039/C6OB00036C
Abstract
An efficient and green method for the α-hydroxylation of substituted ketones has been developed. This method includes the in situ conversion of various ketones into the corresponding silyl enol ethers and their oxidation to the corresponding α-hydroxy ketones. Two protocols have been established leading either to protected α-hydroxy carbonyls or free α-hydroxy ketones. Both procedures are easy to follow and lead to good to high yields for a variety of ketones.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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