Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin?
Organic Chemistry Frontiers Pub Date: 2017-09-06 DOI: 10.1039/C7QO00648A
Abstract
A diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin with potent anticancer activities was explored. The synthesis was based on a highly efficient gold-catalyzed glycosylation reaction with alkynylbenzoate 3-aminoglycosides as glycosyl donors. According to this strategy, a small library containing digitoxin and digoxin analogues with various 3-aminosugar scaffolds was successfully constructed.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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