Graphene oxide mediated thiolation of indoles in water: a green and sustainable approach to synthesize 3-sulfenylindoles?
Organic Chemistry Frontiers Pub Date: 2018-11-26 DOI: 10.1039/C8QO00726H
Abstract
An atom economical and transition-metal and iodine free procedure of graphene oxide (a heterogeneous, recyclable, inexpensive, and environment-friendly carbocatalyst) mediated thiolation of indoles, using thiols as a thiolating reagent, has been developed. This methodology provides a catalyst-recyclable and organic-solvent-free protocol to afford 3-sulfenylindoles with good functional group tolerance and broad substrate scope.
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Journal Name：Organic Chemistry Frontiers
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