Facile access to internally functionalized dendrimers through efficient and orthogonal click reactions?

Chemical Communications Pub Date: 2010-01-28 DOI: 10.1039/B921598K

Abstract

A simple synthetic strategy has been developed for accessing internally functionalized dendrimers. The key feature of this approach is the use of two orthogonal and efficient reactions—‘epoxy–amine’ and ‘thiol–ene’ coupling—for rapid growth of the dendritic scaffold. This sequence of reactions allows for the introduction of reactive hydroxyl groups at each dendritic layer.

Graphical abstract: Facile access to internally functionalized dendrimers through efficient and orthogonal click reactions
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