A light-up endoplasmic reticulum probe based on a rational design of red-emissive fluorogens with aggregation-induced emission?

Chemical Communications Pub Date: 2017-08-21 DOI: 10.1039/C7CC05205G

Abstract

Fine-tuning electron acceptors through changing one cyano group to an amide generates a more stable and emissive fluorophore with the character of aggregation-induced emission. Conjugation between the new fluorophore and CFFKDEL generated an excellent ER targeting light-up probe with high specificity and good photostability.

Graphical abstract: A light-up endoplasmic reticulum probe based on a rational design of red-emissive fluorogens with aggregation-induced emission
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