First report on bio-catalytic N-formylation of amines using ethyl formate?
Chemical Communications Pub Date: 2017-01-30 DOI: 10.1039/C6CC07679C
Abstract
A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also works on a large scale in high yield.
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Journal Name:Chemical Communications
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CAS no.: 89640-58-4