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Facile P,N-heterocycle synthesis via tandem aminomethylation–cyclization of H-phosphinate building blocks?

Organic & Biomolecular Chemistry Pub Date: 2009-11-05 DOI: 10.1039/B917428A

Abstract

Various heterocycles containing phosphorus and nitrogen are easily synthesized from readily available H-phosphinate building blocks. Aminomethylation of these H-phosphinates is followed by in situ cyclization through substitution or cross-coupling to produce novel heterocycles in moderate to good yields.

Graphical abstract: Facile P,N-heterocycle synthesis via tandem aminomethylation–cyclization of H-phosphinate building blocks

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Organic & Biomolecular Chemistry

Journal Name：Organic & Biomolecular Chemistry

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