Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a]indoles?

RSC Advances Pub Date: 2015-11-18 DOI: 10.1039/C5RA17056G

Abstract

A novel series of oxopyrazino[1,2-a]indole derivatives were prepared via a two-step synthetic procedure including a Ugi-four-component reaction followed by the transition metal-free intramolecular hydroamination of Ugi adducts in the presence of KOt-Bu in DMF at room temperature. Density functional theory (DFT) calculations were also performed to elucidate the mechanistic aspects of the reaction.

Graphical abstract: Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a]indoles
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