Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides?

Chemical Communications Pub Date: 2012-04-18 DOI: 10.1039/C2CC18160F

Abstract

Disulfide- and terminal alkyne-modified magnetic silica particles (DA-MSPs) were synthesized and used to covalently capture and reductively release azido glycopeptides via click chemistry and dithiothreitol treatment. Using DA-MSPs, an efficient and specific enrichment method for separating azido glycopeptides has been developed.

Graphical abstract: Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides
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