Electrochemical evaluation of a boron-doped diamond electrode for simultaneous determination of an antihypertensive ternary mixture of amlodipine, hydrochlorothiazide and valsartan in pharmaceuticals

Analytical Methods Pub Date: 2014-12-03 DOI: 10.1039/C4AY02511C

Abstract

The simultaneous voltammetric determination of a ternary mixture containing antihypertensive drugs amlodipine (AML), hydrochlorothiazide (HCTZ) and valsartan (VAL) by square-wave voltammetry using a cathodically pretreated boron-doped diamond electrode is reported for the first time. Three very well-resolved and reproducible oxidative processes of AML, HCTZ and VAL were found at 0.781 V, 1.14 V and 1.41 V, respectively, in Britton–Robinson buffer solution (pH 5.0). The linearity ranges were 4.9 × 10?7–7.2 × 10?6 mol L?1, 2.9 × 10?6–4.5 × 10?5 mol L?1, and 9.7 × 10?6–1.3 × 10?4 mol L?1 for AML, HCTZ and VAL, with detection limits of 2.3 × 10?7 mol L?1, 7.5 × 10?7 mol L?1, and 6.2 × 10?6 mol L?1, respectively. The proposed method was successfully applied to the simultaneous analysis of these antihypertensive drugs in their combined pharmaceutical tablets available in the market.

Graphical abstract: Electrochemical evaluation of a boron-doped diamond electrode for simultaneous determination of an antihypertensive ternary mixture of amlodipine, hydrochlorothiazide and valsartan in pharmaceuticals
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