A highly efficient dual catalysis approach for C-glycosylation: addition of (o-azaaryl)carboxaldehyde to glycals?

Chemical Communications Pub Date: 2014-09-15 DOI: 10.1039/C4CC06111J

Abstract

A novel and efficient dual catalysis approach by concurrent activation of glycals and (o-azaaryl)-carboxaldehydes using palladium and N-heterocyclic carbene has been developed. The two electrophiles could react after activation through formation of the Breslow intermediate and a π-allyl Pd complex, widening the scope of reacting glycosylation partners and opening up possibilities for future glycosylation.

Graphical abstract: A highly efficient dual catalysis approach for C-glycosylation: addition of (o-azaaryl)carboxaldehyde to glycals
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