Enantioselective electrophilic cyanation of β-keto amides catalysed by a cinchona organocatalyst?
Organic & Biomolecular Chemistry Pub Date: 2017-09-01 DOI: 10.1039/C7OB01782K
Abstract
An operationally simple protocol for the enantioselective electrophilic α-cyanation of β-keto amides catalyzed by cinchona-derived catalysts has been demonstrated. The resulting products could be obtained with good to high enantioselectivities (up to 88% ee) and with excellent yields (up to 94%) by employing the mild active 4-acetylphenyl cyanate as the cationic cyano source in the catalytic asymmetric α-cyanation reaction.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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