Efficient iodine-catalyzed one pot synthesis of highly functionalised pyrazoles in water
New Journal of Chemistry Pub Date: 2013-11-18 DOI: 10.1039/C3NJ01149F
Abstract
An efficient one pot multi-component sequential reaction of phenyl hydrazine, malanonitrile and a diverse range of aldehydes to afford highly functionalised pyrazoles is reported. The reaction proceeds in water using molecular iodine as a catalyst, with no by-product formation, and involves simple operation requiring no column chromatography. Thus, this protocol fulfils all of the criteria that define green chemistry.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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