Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin?
Chemical Communications Pub Date: 2019-12-18 DOI: 10.1039/C9CC08908J
Abstract
Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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