Efficient resolution of 2,2′-dihydroxy-1,1′-binaphthyl by inclusion complexation with chiral N-(3-chloro-2-hydroxypropyl)-N,N,N-trimethylammonium chloride?

Organic & Biomolecular Chemistry Pub Date: 2004-01-19 DOI: 10.1039/B314040G

Abstract

The complete resolution of 2,2′-dihydroxy-1,1′-binaphthyl into its enantiomers by inclusion complexation with a commercially available derivative of choline, is reported. The two enantiomers are recovered in >99% ee from the inclusion complexes by simple dissolution in a diethyl ether–water medium and the resolving agent can be recycled.

Graphical abstract: Efficient resolution of 2,2′-dihydroxy-1,1′-binaphthyl by inclusion complexation with chiral N-(3-chloro-2-hydroxypropyl)-N,N,N-trimethylammonium chloride
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