Efficient palladium-catalyzed synthesis of 3-aryl-4-indolylmaleimides

Organic & Biomolecular Chemistry Pub Date: 2008-02-14 DOI: 10.1039/B719160J

Abstract

Improved palladium catalysts for the Suzuki coupling of 3-bromo-1-methyl-4-(2-methyl-3-indolyl)maleimide have been developed. The coupling of both aryl- and heteroarylboronic acids proceeds smoothly in good to excellent yields at low catalyst loading.

Graphical abstract: Efficient palladium-catalyzed synthesis of 3-aryl-4-indolylmaleimides
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