Direct defluorinative amidation–hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines?
Organic & Biomolecular Chemistry Pub Date: 2018-10-18 DOI: 10.1039/C8OB02322K
Abstract
A novel and efficient method for the synthesis of arylacetamides by the reactions of gem-difluoroalkenes with N,N-dialkylformamides, and primary and secondary amines with the assistance of KOtBu and water was developed.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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