Divergent syntheses of okaramines C, J, L, and S–U?
Organic & Biomolecular Chemistry Pub Date: 2020-05-04 DOI: 10.1039/D0OB00587H
Abstract
The total synthesis of six novel okaramines (C, J, L, and S–U) was accomplished with a precise synthesis scheme involving a few steps and a practical yield of 6.7%–23% was obtained. The significance of this study includes the design of a successful and convenient synthesis method for preparation of 3a-hydroxy-pyrrolo[2,3-b]-indole and C-7 prenylated L-tryptophan derivatives using a nucleophilic attack of cyclopropylazetoindoline and an aza-Claisen rearrangement of N-reverse-prenyl tryptophan, respectively.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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