Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase?
RSC Medicinal Chemistry Pub Date: 2019-12-16 DOI: 10.1039/C9MD00511K
Abstract
The cGMP-dependent protein kinase in Plasmodium falciparum (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in malaria models are not optimal. This communication describes initial optimization of a structurally distinct class of PfPKG inhibitors.
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Journal Name：RSC Medicinal Chemistry
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CAS no.: 89640-58-4
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