Direct real-time detection of single proteins using silicon nanowire-based electrical circuits?
Nanoscale Pub Date: 2016-08-19 DOI: 10.1039/C6NR04103E
Abstract
We present an efficient strategy through surface functionalization to build a single silicon nanowire field-effect transistor-based biosensor that is capable of directly detecting protein adsorption/desorption at the single-event level. The step-wise signals in real-time detection of His-tag F1-ATPases demonstrate a promising electrical biosensing approach with single-molecule sensitivity, thus opening up new opportunities for studying single-molecule biophysics in broad biological systems.
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Journal Name：Nanoscale
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CAS no.: 89640-58-4
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