Direct synthesis of 8-acylated quinoline N-oxides via palladium-catalyzed selective C–H activation and C(sp2)–C(sp2) cleavage?

New Journal of Chemistry Pub Date: 2018-12-21 DOI: 10.1039/C8NJ05374J

Abstract

An efficient method for the synthesis of 8-acylated quinoline N-oxides from the reaction of quinoline N-oxides with α-diketones via C–C bond cleavage was developed. A variety of quinoline N-oxides and α-diketones with different groups was well tolerated in this system.

Graphical abstract: Direct synthesis of 8-acylated quinoline N-oxides via palladium-catalyzed selective C–H activation and C(sp2)–C(sp2) cleavage
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