Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts?

Chemical Communications Pub Date: 2014-11-04 DOI: 10.1039/C4CC07643E

Abstract

A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.

Graphical abstract: Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts
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