Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents?
Dalton Transactions Pub Date: 2018-09-10 DOI: 10.1039/C8DT03448F
Abstract
We report a novel series of cobalt(III)-polypridyl complexes, 4–6, that can selectively release diflunisal, a nonsteroidal anti-inflammatory drug, under reducing conditions. Remarkably, the 1,10-phenanthroline-bearing complex 5 displays selective potency towards hard-to-kill cancer stem cells (CSCs) (IC50 = 2.1 ± 0.1 μM) over bulk cancer (IC50 = 3.9 ± 0.2 μM) and normal cells (IC50 = 21.2 ± 1.3 μM). This complex induces CSC apoptosis by DNA damage and cyclooxygenase-2 inhibition.
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Journal Name：Dalton Transactions
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CAS no.: 89640-58-4
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