Continuous flow Negishi cross-couplings employing silica-supported Pd-PEPPSI–IPr precatalyst?

Catalysis Science & Technology Pub Date: 2016-03-15 DOI: 10.1039/C6CY00331A

Abstract

The synthesis of a triethoxysilyl functionalised Pd-PEPPSI–IPr complex prepared via azide–alkyne cycloaddition is described. The complex was immobilised onto silica gel and applied as a heterogeneous catalyst in the Negishi reaction. The catalyst was active in both batch and continuous flow operation and was particularly effective for the coupling of heteroaryl chlorides. Long-term continuous flow experiments demonstrated good catalyst activity over fifteen hours.

Graphical abstract: Continuous flow Negishi cross-couplings employing silica-supported Pd-PEPPSI–IPr precatalyst
Recommended Literature