A FRET probe for the detection of alkylating agents?

Chemical Communications Pub Date: 2019-06-28 DOI: 10.1039/C9CC04391H

Abstract

Herein, we describe a new strategy for the detection of reactive alkylating agents such as alkyl halides. These toxic compounds react with a FRET-based profluorescent probe, triggering a self-immolative elimination at room temperature, thus leading to a fluorescence signal.

Graphical abstract: A FRET probe for the detection of alkylating agents
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