A guanylurea-functionalized conjugated polymer enables RNA interference in ex vivo human airway epithelium?

Chemical Communications Pub Date: 2019-06-12 DOI: 10.1039/C9CC02856K

Abstract

We demonstrate a successful target gene knockdown in ex vivo normal human bronchial epithelium (NHBE) cells covered with mucus layers using the guanylurea functionalization technique modulating the chemical environment at the positive charge of a gene carrier.

Graphical abstract: A guanylurea-functionalized conjugated polymer enables RNA interference in ex vivo human airway epithelium
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