A green and efficient method for the synthesis of pyrroles using a deep eutectic solvent ([CholineCl][ZnCl2]3) under solvent-free sonication?
New Journal of Chemistry Pub Date: 2017-09-12 DOI: 10.1039/C7NJ02396K
Abstract
An efficient deep eutectic solvent-based synthesis of pyrroles under ultrasound irradiation has been developed to provide a significant improvement of the yield up to 99% in a short reaction time. The synthesis of pyrroles is highly atom-economical, producing water as the sole byproduct. In addition, [CholineCl][ZnCl2]3 is easily synthesized from commercially available choline chloride and zinc chloride via a cost-effective and environmentally benign pathway. The obtained [CholineCl][ZnCl2]3 has been characterized by FT-IR, 1H-NMR, 13C-NMR, HRMS (ESI), Raman, and TGA. Five new pyrroles are synthesized by the current method. Moreover, [CholineCl][ZnCl2]3 could be reused up to four times without significant loss of catalytic activity.
![Graphical abstract: A green and efficient method for the synthesis of pyrroles using a deep eutectic solvent ([CholineCl][ZnCl2]3) under solvent-free sonication](http://scimg.chem960.com/usr/1/C7NJ02396K.jpg)
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Journal Name：New Journal of Chemistry
research_products
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CAS no.: 89640-58-4
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