Detailed study of the reversible addition–fragmentation chain transfer polymerization and co-polymerization of 2-methacryloyloxyethyl phosphorylcholine?

Polymer Chemistry Pub Date: 2010-11-11 DOI: 10.1039/C0PY00300J

Abstract

In this paper, we report on a detailed study of the reversible addition–fragmentation chain transfer (RAFT) polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC). The RAFT polymerization conditions were carefully monitored and it was noted that well-defined homopolymers with ideal low polydispersity (Mw/Mn < 1.2) could be achieved in methanol using 4-cyanopentanoic acid dithiobenzoate (CTP) as a chain transfer agent and 4,4′-azobis(4-cyanovaleric acid) (ACVA) as an initiator. A series of well-defined block copolymers having a range of compositions and molecular weight were prepared using poly(MPC) as the macroCTA. Statistical MPC-based copolymers of biological relevance were also synthesized and characterized.

Graphical abstract: Detailed study of the reversible addition–fragmentation chain transfer polymerization and co-polymerization of 2-methacryloyloxyethyl phosphorylcholine
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