A general approach to the quantification of resin-bound functional groups by NMR

New Journal of Chemistry Pub Date: 2004-10-08 DOI: 10.1039/B406513A

Abstract

There has been a continuing need for sensitive, accurate and rapid methods to monitor functional loading of insoluble supports for solid phase synthesis. The present articles reports our findings regarding functional group loading quantification using 1H NMR. Results obtained for supported amino, hydroxyl and NH-Fmoc groups are in agreement with those calculated using well-established methods and demonstrate that the strategy of looking, either at the excess reagent left in solution (NH2 and OH), or at the protecting group derivatives released from the polymer (Fmoc), is a viable approach to resin loading quantification.

Graphical abstract: A general approach to the quantification of resin-bound functional groups by NMR
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