Covalent assistance to supramolecular synthesis: directing the supramolecular assembly of co-crystals by in situ modification of hydrogen bonding functionality?

CrystEngComm Pub Date: 2010-11-01 DOI: 10.1039/C0CE00347F

Abstract

Nicotinic acid hydrazide (niazid) readily co-crystallizes with carboxylic acids in methanol to form a 2-D sheet structure that utilizes all three H bond donors on the carbohydrazide functional group. In acetone solution niazid undergoes a condensation reaction with the solvent, which replaces the amine group with a hydrocarbon group leaving only one hydrogen bond donor on the modified niazid molecule, now containing a N-acylhydrazone functional group. The resulting reduced hydrogen bonding functionality leads to a new supramolecular assembly when co-crystallized with the same dicarboxylic acids.

Graphical abstract: Covalent assistance to supramolecular synthesis: directing the supramolecular assembly of co-crystals by in situ modification of hydrogen bonding functionality
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