Design of an environmentally sensitive fluorescent 8-aza-7-deaza-2′-deoxyadenosine derivative with dual fluorescence for the specific detection of thymine?
Organic & Biomolecular Chemistry Pub Date: 2013-10-16 DOI: 10.1039/C3OB41757C
Abstract
A novel environmentally sensitive fluorescent (ESF) purine nucleoside, cnaA, was synthesized and its photophysical properties were investigated. The base-modified fluorescent nucleoside cnaA exhibited remarkable solvatochromicity and environmentally sensitive dual fluorescence. By using cnaA, we have developed highly thymine (T) selective fluorescent DNA probes that can sense the corresponding T in a target DNA/RNA sequence, as measured by a distinct change in emission wavelength.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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