Copper-catalyzed aerobic oxidative C–C bond cleavage of simple ketones for the synthesis of amides

Organic & Biomolecular Chemistry Pub Date: 2020-08-28 DOI: 10.1039/D0OB01601B

Abstract

A Cu-catalyzed oxidative amidation of simple ketones with amines via carbon–carbon (C–C) bond cleavage has been developed. A number of aryl and alkyl ketones could be easily converted to amides using cheap copper salt as the catalyst and O2 as the oxidant with a wide range of amines, including primary and secondary amines. This method shows a notable advantage of the broad scope for the substrate, thus providing a practical approach to amides. A plausible mechanism is proposed based on the preliminary experiments.

Graphical abstract: Copper-catalyzed aerobic oxidative C–C bond cleavage of simple ketones for the synthesis of amides
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