Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki–Miyaura coupling?

Organic & Biomolecular Chemistry Pub Date: 2012-03-20 DOI: 10.1039/C2OB25373A

Abstract

An atropo-diastereoselective synthesis with dr up to 98/2 towards the biaryl subunit of vancomycin based on the use of enantiopure β-hydroxysulfoxide derivatives as novel chiral auxiliary is reported.

Graphical abstract: Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki–Miyaura coupling
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