Construction of key building blocks towards the synthesis of cortistatins?
Organic & Biomolecular Chemistry Pub Date: 2020-03-02 DOI: 10.1039/D0OB00170H
Abstract
This work reports the construction of key building blocks towards the synthesis of cortistatins; a family of steroidal alkaloids. Cortistatin A, being a primary target due to its superior biological properties over other congeners, has been prepared by two different synthetic routes. Synthesis of the precursor to the heavily substituted A-ring starting from D-glucose and construction of the DE-ring junction employing a Hajos–Parrish ketone as a chiral pool have been demonstrated. Efforts are underway to assemble these key fragments and build towards the total synthesis of cortistatin A.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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