Copper-catalyzed hydroboration of propargyl-functionalized alkynes in water?

RSC Advances Pub Date: 2016-06-15 DOI: 10.1039/C6RA14465A

Abstract

The Cu-catalyzed hydroboration of alkynes in operationally simple and environmentally friendly conditions is reported. The reactions are performed in water, at room temperature, under micellar catalysis. Conditions to form the α or β borylated products selectively have been found and as an application a protocol for the tandem hydroboration/Suzuki coupling in water was developed.

Graphical abstract: Copper-catalyzed hydroboration of propargyl-functionalized alkynes in water
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