Copper-catalyzed 1,1-alkynylalkylation of alkynes: access toward conjugated enynes?
Organic Chemistry Frontiers Pub Date: 2020-08-24 DOI: 10.1039/D0QO00826E
Abstract
A copper-catalyzed 1,1-alkynylalkylation of alkynes with α-haloacetamides is realized. This reaction provides a practical and simple synthetic methodology for various conjugated enynes with excellent functional group compatibility and high stereo- and regioselectivity. The mechanism of the tandem copper-catalyzed Sonogashira coupling reaction and syn-alkynylcupration of allenamides has been investigated.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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