“On water” sp3–sp2 cross-couplings between benzylic and alkenyl halides?

Chemical Communications Pub Date: 2011-04-12 DOI: 10.1039/C1CC11087J

Abstract

Organic-solvent-free cross-couplings between benzylic and alkenyl halides have been developed. Various alkenyl halides can be efficiently benzylated by combining the precursor halides in the presence of Zn dust and a Pd catalyst at room temperature, in water as the only medium.

Graphical abstract: “On water” sp3–sp2 cross-couplings between benzylic and alkenyl halides
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