Copper-catalyzed cascade reactions of N-(2-bromoallyl)amines with KHCO3 as the C1 source: an efficient process for the synthesis of oxazolidin-2-ones?

RSC Advances Pub Date: 2014-04-28 DOI: 10.1039/C4RA02304H

Abstract

A novel synthesis of oxazolidin-2-ones by carbamic acid formation and a subsequent copper-catalyzed intramolecular vinylation from N-(2-bromoallyl)amines and KHCO3 was developed. KHCO3 was used as a C1 source and base in this efficient and convenient cascade process.

Graphical abstract: Copper-catalyzed cascade reactions of N-(2-bromoallyl)amines with KHCO3 as the C1 source: an efficient process for the synthesis of oxazolidin-2-ones
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