Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases??

Chemical Communications Pub Date: 2010-05-11 DOI: 10.1039/C0CC00585A

Abstract

A straightforward, high-yielding, chemoenzymatic total synthesis of enantiopure (S)-Rivastigmine was developed using various ω-transaminases for the asymmetric amination of appropriate acetophenone precursors. Optimisation of the biotransformation allowed scale-up and the total synthesis of (S)-Rivastigmine.

Graphical abstract: Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases
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