Cinchonidine thiourea catalyzed asymmetric addition of phenols to oxindole derivatives?
RSC Advances Pub Date: 2014-11-12 DOI: 10.1039/C4RA09805F
Abstract
A highly enantioselective Friedel–Crafts reaction of activated phenols with isatin derivatives has been developed employing Cinchona-derived thiourea as an organocatalyst. A variety of biologically important 3-aryl-3-hydroxy-2-oxindoles have been synthesized using phenols in good to excellent yield with good enantioselectivity (up to 92% ee).
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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