Pyrrolidines
Pyrrolidines are a class of heterocyclic compounds characterized by the presence of a five-membered ring containing one nitrogen atom. Widely used in organic synthesis, these secondary amines exhibit unique chemical properties that make them versatile building blocks for various pharmaceuticals and agrochemicals. Pyrrolidines can be synthesized through several methods, including amidolysis of cyclic carbonates or ureides, as well as by the reduction of pyrroles. Their amine functionality allows for facile derivatization, making them valuable in the development of drugs targeting a wide range of biological pathways. Additionally, their hydrophilic nature and low toxicity contribute to their application in both drug design and functional materials.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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3-chloropyrrolidine;hydrochloride | 10603-47-1 | C4H9Cl2N |
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1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole | 5661-03-0 | C7H13N |
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tert-butyl N-[2-(pyrrolidin-3-yl)ethyl]carbamate | 169750-93-0 | C11H22N2O2 |
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2-(Aminomethyl)pyrrolidine-1-carbaldehyde | 145544-74-7 | C6H12N2O |
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octahydrocyclopenta[c]pyrrol-4-one hydrochloride | 127430-46-0 | C7H12ClNO |
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[(3-fluoropyrrolidin-3-yl)methyl]dimethylamine | 125032-78-2 | C7H15FN2 |
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2-[(3R)-pyrrolidin-3-yl]acetic acid | 122442-01-7 | C6H11NO2 |
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(R)-(+)-2-(Methoxymethyl)-1-pyrrolidinecarboxaldehyde | 121817-71-8 | C7H13NO2 |
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tert-butyl N-[(7R)-5-azaspiro[2.4]heptan-7-yl]carbamate | 127199-44-4 | C11H20N2O2 |
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3-Methylpyrrolidin-3-ol | 125032-87-3 | C5H11NO |
Related Literature
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J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
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Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
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Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
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Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
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Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
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